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Arch Otolaryngol Head Neck Surg. 2008;134(10):1118-1119.

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Diagnosis: Alveolar rhabdomyosarcoma

Rhabdomyosarcomas comprise a group of malignant soft tissue neoplasms that share the histopathologic features of striated muscle morphogenesis.¹ It is a common misconception that all rhabdomyosarcomas arise from skeletal muscle; however, these tumors presumably arise from some type of mesenchymal stem cell or precursor and, as such, often arise in tissues that are devoid of striated muscle fibers. Although rhabdomyosarcomas have a very strong propensity for pediatric patients, a significant number of them have been reported in the adult population.² Approximately 40% of rhabdomyosarcomas occur in the head and neck; other common sites include the genitourinary tract, extremities, and trunk.³ In the head and neck, rhabdomyosarcomas can occur in the orbit, oral cavity, pharynx, esophagus, neck, face, and parameningeal sites such as the paranasal sinuses, nasal cavity, middle ear, and mastoid. They may also rarely present as radiation-induced tumors years after radiotherapy. While most cases of rhabdomyosarcoma . . . [Full Text of this Article]

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