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Arch Otolaryngol Head Neck Surg. 2007;133(7):730-731.

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Diagnosis: Dermatopathic lymphadenitis (DL)

Dermatopathic lymphadenitis characteristically presents as a single or multiple enlarged axillary or inguinal lymph nodes. The lymph nodes are usually discrete, superficial, nontender, firm, and freely movable.¹ Presentation as an enlarged neck mass is exceedingly rare. The disease is typically associated with a benign pruritic skin disorder. It is frequently noted as one of many findings in a systemic disease (eg, chronic lymphocytic leukemia or AIDS). It may also be associated with a cutaneous neoplasm (eg, mycosis fungoides or Sézary syndrome) or discovered as an isolated finding.

Dermatopathic lymphadenitis was first described as lipomelanotic reticulosis because of the obvious accumulation of lipids and melanin pigment in the cortical region of lymph nodes.² Further research that elucidated a relationship between the characteristic appearance of the lymph nodes and pruritic skin diseases led to the name dermatopathic lymphadenitis.² The histologic and immunohistochemical features of DL have been well described. The lymph . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2007;133(7):729.
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