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Sinonasal Disease and Nasal Saline—Reply
Valeria Raia, MD;
Angela Sepe, MD;
Mariano Cimmino, MD;
Massimiliano Nardone, MD;
Matteo Cavaliere, MD;
Angela Plantulli, MD;
Giuseppina Mazzarella, MD
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In reply
We appreciate the comments from Acar and Karabulut regarding our article "Dornase Alfa as Postoperative Therapy in Cystic Fibrosis Sinonasal Disease." There have been a number of important additions to the literature regarding the efficacy of dornase alfa therapy since the publication of our work.1-2 These new studies have added to the European and American experience with the clinical use of dornase alfa as an anti-inflammatory agent.
Several studies have suggested that there is a relationship between sinusitis and chronic pulmonary disease in children, but it has not been clearly demonstrated for cystic fibrosis. On the other hand, sinonasal disease with or without nasal polyps is a common feature in patients with cystic fibrosis and plays an important role in quality of life and morbidity. Factors associated . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTERS
Dornase Alfa as Postoperative Therapy in Cystic Fibrosis Sinonasal Disease
Mariano Cimmino, Massimiliano Nardone, Matteo Cavaliere, Angela Plantulli, Angela Sepe, Valeria Esposito, Giuseppina Mazzarella, and Valeria Raia
Arch Otolaryngol Head Neck Surg. 2005;131(12):1097-1101.
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Sinonasal Disease and Nasal Saline
Baran Acar and Hayriye Karabulut
Arch Otolaryngol Head Neck Surg. 2007;133(6):625.
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