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Sinonasal Disease and Nasal Saline
Baran Acar, MD;
Hayriye Karabulut, MD
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We read with interest the article by Cimmino et al1 in the December 2005 issue of the Archives. The authors concluded that dornase alfa is superior to placebo (saline in this study) for the treatment of patients with cystic fibrosis and nasal symptoms. However, we think that the use of isotonic saline solution as placebo is inappropriate. It is well known that nasal washing with saline solution facilitates nasal drainage and cleans the airway of any postnasal discharge; it can be effective when applied appropriately (5 dropperfuls in each nostril at least 4 times a day).2-3 Saline solution irrigation has been found to reduce inflammatory mediators (histamine, prostaglandin D2, and leukotriene C4) and allergens in nasal secretions.4 Therefore, nasal saline washing with the correct technique is a cheap and effective method for treating inflammatory conditions of the upper respiratory tract such . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
Sinonasal Disease and Nasal Saline—Reply
Valeria Raia, Angela Sepe, Mariano Cimmino, Massimiliano Nardone, Matteo Cavaliere, Angela Plantulli, and Giuseppina Mazzarella
Arch Otolaryngol Head Neck Surg. 2007;133(6):625.
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RELATED ARTICLE
Dornase Alfa as Postoperative Therapy in Cystic Fibrosis Sinonasal Disease
Mariano Cimmino, Massimiliano Nardone, Matteo Cavaliere, Angela Plantulli, Angela Sepe, Valeria Esposito, Giuseppina Mazzarella, and Valeria Raia
Arch Otolaryngol Head Neck Surg. 2005;131(12):1097-1101.
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