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Baran Acar, MD; Hayriye Karabulut, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with interest the article by Cimmino et al¹ in the December 2005 issue of the Archives. The authors concluded that dornase alfa is superior to placebo (saline in this study) for the treatment of patients with cystic fibrosis and nasal symptoms. However, we think that the use of isotonic saline solution as placebo is inappropriate. It is well known that nasal washing with saline solution facilitates nasal drainage and cleans the airway of any postnasal discharge; it can be effective when applied appropriately (5 dropperfuls in each nostril at least 4 times a day).^2-3 Saline solution irrigation has been found to reduce inflammatory mediators (histamine, prostaglandin D₂, and leukotriene C₄) and allergens in nasal secretions.⁴ Therefore, nasal saline washing with the correct technique is a cheap and effective method for treating inflammatory conditions of the upper respiratory tract such . . . [Full Text of this Article]

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