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Arch Otolaryngol Head Neck Surg. 2007;133(3):305.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa

Liposarcoma is the most common soft tissue sarcoma in adults, representing 20% of all sarcomas.¹ Liposarcoma predominantly affects older adults and preferentially occurs in the extremities and retroperitoneum. The World Health Organization currently recognizes 4 subtypes: well-differentiated liposarcoma/atypical lipomatous tumor (WDLS/ALT), myxoid liposarcoma, dedifferentiated liposarcoma, and PLS.²

Pleomorphic liposarcoma represents less than 5% of all liposarcomas. It typically affects older adults (>50 years), without a sex predilection, and although it has been reported in almost any site, it most commonly involves the extremities and retroperitoneum.^2-3 It is a high-grade sarcoma that contains a variable number of pleomorphic lipoblasts and does not contain a component of well-differentiated liposarcoma.² Unlike other types of liposarcoma, it is less commonly positive for S100 protein, which is present in less than 50% of cases.²

The differential diagnosis of PLS includes other pleomorphic sarcomas, most importantly pleomorphic malignant fibrous histiocytoma, pleomorphic rhabdomyosarcoma, and dedifferentiated liposarcoma.³ It . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2007;133(3):303.
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