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Pathology Quiz Case 2: Diagnosis
Arch Otolaryngol Head Neck Surg. 2007;133(3):305.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Diagnosis: Pleomorphic liposarcoma (PLS) of the retrotonsillar fossa
Liposarcoma is the most common soft tissue sarcoma in adults, representing 20% of all sarcomas.1 Liposarcoma predominantly affects older adults and preferentially occurs in the extremities and retroperitoneum. The World Health Organization currently recognizes 4 subtypes: well-differentiated liposarcoma/atypical lipomatous tumor (WDLS/ALT), myxoid liposarcoma, dedifferentiated liposarcoma, and PLS.2
Pleomorphic liposarcoma represents less than 5% of all liposarcomas. It typically affects older adults (>50 years), without a sex predilection, and although it has been reported in almost any site, it most commonly involves the extremities and retroperitoneum.2-3 It is a high-grade sarcoma that contains a variable number of pleomorphic lipoblasts and does not contain a component of well-differentiated liposarcoma.2 Unlike other types of liposarcoma, it is less commonly positive for S100 protein, which is present in less than 50% of cases.2
The differential diagnosis of PLS includes other pleomorphic sarcomas, most importantly pleomorphic malignant fibrous histiocytoma, pleomorphic rhabdomyosarcoma, and dedifferentiated liposarcoma.3 It . . . [Full Text of this Article]
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Pathology Quiz Case 2
Deborah J. Chute, Jamie Shutter, and Stacey E. Mills
Arch Otolaryngol Head Neck Surg. 2007;133(3):303.
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