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Arch Otolaryngol Head Neck Surg. 2007;133(10):1065-1066.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Follicular lymphoma (FL), grade 3, pediatric type

Follicular lymphoma, while common in adults, is rare in children, representing only 1% to 2% of all pediatric lymphomas. There is a male predilection, with a male-female ratio of approximately 4:1, and the median age at presentation is 7 years. In contrast to adult FL, pediatric FL often manifests as localized nodal disease in the head and neck region and characteristically has an indolent course. Extranodal presentation occasionally occurs within the gastrointestinal tract, parotid gland, kidneys, and testes.¹

Histologically, pediatric FL demonstrates near-total effacement of the nodal architecture by a follicular growth pattern of CD10/BCL6/CD19-positive and BCL2-negative B lymphocytes; often, very large, expansive, and confluent follicles are seen without well-defined mantle zones.² The lymphocytes consist of a combination of centrocytes with irregular clefted nuclei and centroblasts with prominent nucleoli. Histologic grade, as outlined by the World Health Organization classification, is based on the number of large centroblasts seen per high-power . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2007;133(10):1063.
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