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Arch Otolaryngol Head Neck Surg. 2007;133(10):1064.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Foreign body reaction to facial silicone gel implantation

The hematoxylin-eosin–stained sections revealed an inflammatory infiltrate that was composed of lymphocytes, histiocytes, and foreign body giant cells located near cavities of different sizes (Figures 3 and 4). The empty spaces produced a "Swiss cheese" appearance in the deep dermis and in the subcutaneous fat. Immunocytochemical studies using CD3 and CD20 antisera demonstrated a paucity of T and B lymphocytes, with a higher number of T cells. CD68 antiserum demonstrated several hundred histiocytes. This histologic picture, along with a clinical history of injections, is consistent with a foreign body reaction.

Figure appears in full text version. Figure 3.

Figure appears in full text version. Figure 4.

In biopsy specimens of affected skin, the most common histopathologic findings are multinucleated giant histiocytes with empty cytoplasmic vacuoles. Under conventional light microscopy, silicon is a translucent, clear, mucoid, refractile material. Polarization microscopy can also be used as an aid to diagnosis. With thick sectioning, tiny yellow refractile spicules that are not birefringent under . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2007;133(10):1062.
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