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Arch Otolaryngol Head Neck Surg. 2006;132:1015-1016.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Subglottic amyloidosis

Amyloidosis of the larynx is rare, representing fewer than 1% of all benign laryngeal lesions.¹ Subglottic stenosis is usually traumatic in origin. Other benign etiologies include relapsing polychondritis, amyloidosis, sarcoidosis, and Wegener granulomatosis.² Laryngeal amyloid deposits are characterized by extracellular subepithelial proteinaceous deposits, which may have a nodular or diffuse pattern.³ The disease occurs most commonly in the fifth to seventh decades of life, with a male predominance (male-female ratio, 2:1).²

Amyloidosis can affect many organs simultaneously (systemic amyloidosis) or just 1 organ or tissue (localized amyloidosis). Laryngeal amyloidosis is usually localized.³ Chronic inflammation, infection, and vocal abuse have been proposed as causative factors.^3-4 The sites of preference in the laryngotracheal region in order of frequency are the ventricle, false vocal cord, true vocal cord, epiglottis, aryepiglottic fold, subglottis, and trachea.² Symptoms, when present, are caused by the physical presence, size, and location of the tumor. Subglottic amyloidosis, which may . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2006;132(9):1013.
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