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Arch Otolaryngol Head Neck Surg. 2006;132:456.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)

Rosai-Dorfman disease is a rare benign disorder characterized by massive lymphadenopathy and associated with fever and leukocytosis.¹ It was originally described in the late 1960s by Rosai and Dorfman,² and since its discovery more than 650 cases have been reported.³ Lymphadenopathy, typically cervical, is the most common presentation of this entity and is seen in more than 95% of patients; however, extranodal involvement occurs in approximately one third of patients.⁴ Examples of nonlymphoid sites of involvement include the head and neck, paranasal sinuses, eyes, central nervous system, kidneys, upper respiratory tract, gastrointestinal tract, testicles, temporal bone, and salivary glands.

Rosai-Dorfman disease tends to occur in children and adolescents, with most cases occurring in children younger than 10 years.⁵ It is more commonly seen in blacks, and there is a slight male predominance. Three cases were found in a review of 1332 lymph node pathologic specimens from children in developing countries . . . [Full Text of this Article]

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