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Arch Otolaryngol Head Neck Surg. 2006;132:222.

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Diagnosis: Xanthogranuloma

Xanthogranuloma is a benign lesion of non-Langerhans cell histiocytes. The lesion was first described in children and named juvenile xanthogranuloma by Helwig and Hackney¹ in 1954. An adult form was described in 1976 and noted to be histologically indistinguishable from the childhood form.²

The incidence of xanthogranuloma is unknown because the lesions may regress spontaneously in children or be mistaken for nevi. The lesions present as firm, brown or yellow papules varying from 0.5 to 2.0 cm in diameter. They are usually asymptomatic but may ulcerate or bleed.³ The head and neck region is the most frequently involved area, followed by the trunk and the upper extremities. Extracutaneous sites include the eyes, oral mucosa, and viscera.⁴ There is a slight male predominance observed in children and possibly in adults.^5-6 The majority of xanthogranulomas occur as single lesions, and there is a bimodal distribution for age at onset, with peaks in . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2006;132(2):220.
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