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Arch Otolaryngol Head Neck Surg. 2006;132:1387-1388.

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Diagnosis: Giant cell tumor (GCT) of the temporal bone

Giant cell tumor is a rare primary bone neoplasm that arises from nonosteogenic stromal cells of the bone marrow. It tends to occur in the ends of long bones. Skull involvement is extremely rare, accounting for only 2% of all GCTs.¹ The most common locations in the skull are the sphenoidal, temporal, and ethmoidal bones, because GCTs occur in bones that develop by endochondral rather than membranous ossification.¹ The tumor most commonly presents in the third and fourth decades of life and has a slight female predominance.²

The clinical presentation of GCTs of the skull depends on tumor location. Sphenoidal GCTs may cause headache, visual loss, cranial nerve dysfunction, and endocrinopathy, whereas temporal bone GCTs often present with pain behind the ear, hearing loss, and facial palsy.^3-4 Our patient presented with hearing loss and a palpable painless mass anterior to his ear.

Radiologically, a GCT is typically a nonspecific expansile . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2006;132(12):1385.
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