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Pathology Quiz Case 2
Li-Jen Liao, MD;
Yih-Leong Chang, MD;
Lai-Lei Ting, MD;
Cheng-Ping Wang, MD
National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
Arch Otolaryngol Head Neck Surg. 2006;132:1269.
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A 45-year-old man presented with a 3-month history of blood-tinged sputum in the morning. Physical examination revealed a red granular tumor in the nasopharynx that filled the right side of the pharyngeal recess (Rosenmüller fossa) and bled easily when touched. Magnetic resonance imaging revealed a mass in the nasopharynx (Figure 1) and a retropharyngeal lymph node. Representative hematoxylin-eosinstained sections of the nasopharyngeal tumor showed an intact mucosa lining, with many large, blue, round cells in the submucosa. The cells contained prominent large eccentric nuclei with a clockwise arrangement of the chromatin and abundant basophilic cytoplasm (Figure 2). Immunohistochemical staining demonstrated that the cytoplasm of the cells was strongly positive for common leukocyte antigen and immunoglobulin light chain (Figure 3) but negative for light chain (Figure 4). The complete blood cell . . . [Full Text of this Article]
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