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Interdigitating Dendritic Cell Sarcoma of Cervical Lymph Nodes
Stephen Jo, MD;
Michael J. Babb, MD;
Raymond L. Hilsinger, Jr, MD
Arch Otolaryngol Head Neck Surg. 2006;132:1257-1259.
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INTRODUCTION
Interdigitating dendritic cell sarcoma (IDCS) is a malignant neoplasm that arises from the interdigitating reticular cells of the lymph node. Dendritic cells are a heterogeneous group of antigen-presenting cells that play a major role in innate and adaptive immune responses. Subtypes of dendritic cells include Langerhans cells, interdigitating dendritic cells, follicular dendritic cells, and dermal dendrocytes.1 Interdigitating dendritic cells reside in the T-cell areas of peripheral lymphoid tissue, including the paracortex of lymph node and tonsil, the splenic periarteriolar lymphoid sheaths, and the interfollicular areas of mucosa-associated lymphoid tissue, and are responsible for major histocompatibility complex–restricted stimulation of resting T cells. Interdigitating dendritic cell sarcoma is rare; to our knowledge, only 34 cases have been reported to date.1-4 Lymphadenopathy is the most common physical finding at presentation, and 42% of cases occur in the head and neck.1-2,4 Otolaryngologists . . . [Full Text of this Article]
REPORT OF A CASE
COMMENT
CONCLUSIONS
AUTHOR INFORMATION
Author Affiliations: From the Department of Head and Neck Surgery, Kaiser Permanente Medical Center, Oakland, Calif. Dr Babb is now in private practice, Redding, Calif.
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