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Arch Otolaryngol Head Neck Surg. 2005;131:742-743.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Orbital pseudotumor

Churg-Strauss syndrome is a systemic vasculitis. There are 3 distinct clinical phases—asthma, tissue eosinophilia, and vasculitis—that occur in many, but not all, patients.¹ These phases, and the varied pathologic findings, suggest that the pathophysiologic process of the disorder might evolve over time.

Analysis of tissue biopsy specimens from patients with CSS shows an eosinophil-rich inflammatory infiltrate with granuloma formation in connective tissue and blood vessel walls. Necrotizing vasculitis with fibrinoid changes arises in small to medium-size vessels. It differs from other small to medium-size vessel vasculitides (Wegener granulomatosis and microscopic polyangiitis) clinically because of the presence of asthma and pathologically because of the eosinophilic infiltration of affected tissues.

The following 6 criteria for the diagnosis of CSS were proposed by the American College of Rheumatology in 1990²: (1) asthma, (2) eosinophilia (>10% on differential white blood cell count), (3) mononeuritis multiplex or polyneuropathy, (4) pulmonary infiltrates, (5) paranasal sinusitis, . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2005;131(8):739.
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