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Broadening the Spectrum of Treatment Options for SNHL
Arch Otolaryngol Head Neck Surg. 2005;131:734.
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Sudden SNHL remains one of the many puzzling and frustrating disorders in otolaryngology. Not understanding the pathophysiology of this disorder is one of the greatest limiting factors in developing rational drug therapy. As this excellent article by Marzo states, there are many potential causes, and many different treatment approaches have been developed without rigorous studies to back up their use. Thus, currently we have little idea of how the disease or the potential treatments work.
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Hinrich Staecker, MD, PhD
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Recent studies have suggested a potential role for inflammatory cytokines in a variety of pathologic processes in the inner ear, further supporting the success of steroid use in these disorders.1-2 In addition, models of drug distribution in the inner ear suggest that delivery to the apex of the cochlea may not be adequate.3 There is, however, sufficient evidence at this point to demonstrate that early steroid use is beneficial for hearing . . . [Full Text of this Article]
AUTHOR INFORMATION
Hinrich Staecker, MD, PhD
Author Affiliations: Department of OtolaryngologyHead and Neck Surgery, University of Maryland School of Medicine, Baltimore.
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