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Arch Otolaryngol Head Neck Surg. 2005;131:733-734.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Sudden SNHL continues to present a diagnostic and management dilemma to otolaryngologists. This otologic entity should be considered a syndrome with various causes, including acoustic neuromas. Diagnosis is hindered mainly by the limited availability of in vivo evaluation techniques for inner-ear disorders. Despite these challenges, recent animal studies and clinical research have increased our knowledge regarding the effect of corticosteroids on sudden hearing loss.

Figure appears in full text version. Aristides Sismanis, MD

Rarey and Curtis¹ first reported the presence of glucocorticoid receptors in the spiral ligament and in other parts of the human inner ear. Hearing improvement following administration of glucocorticoids might be due to (1) their anti-inflammatory effect^2-3; (2) increasing stria vascularis synthesis of Na⁺-K⁺ adenosine triphosphatase,⁴ which decreases vascular permeability (particularly to circulating immune mediators)⁵; and (3) increasing cochlear expression of aquaporin 1 and 3.^6-7 The pharmakokenetics of the glucocorticoids have been studied by Parnes et al,⁸ who demonstrated a . . . [Full Text of this Article]

AUTHOR INFORMATION

Aristides Sismanis, MD
Author Affiliations: Virginia Commonwealth University, Richmond.

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