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Head and Neck Squamous Cell Carcinoma in Patients With Fanconi Anemia
Arch Otolaryngol Head Neck Surg. 2005;131:640-641.
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INTRODUCTION
For the practicing otolaryngologist, the list of the causes of premalignant leukoplakia and head and neck squamous cell carcinoma (HNSCC) in patients aged 10 to 60 years without the usual risk factors needs to be expanded to include atypical as well as typical cases of Fanconi anemia (FA). In this issue, Alter et al1 describe HNSCC as a presenting manifestation in an adult patient with FA without anemia, due to somatic hematopoietic mosaicism. Also, the authors report the emerging epidemiological evidence regarding the extraordinarily high risk of HNSCC as the most common solid tumor in teens and adults with FA.2-3 The clinical importance of identifying these patients lies in the high risk for the development of multiple cancers and serious complications or death as a result of chemotherapy or radiotherapy due to the increased sensitivity of tissues to DNA damage. Furthermore, research into prophylactic strategies that can reduce chronic injury . . . [Full Text of this Article]
CLINICAL MANIFESTATIONS OF CHROMOSOMAL INSTABILITY IN PATIENTS WITH FA
CLINICAL IMPORTANCE OF DIAGNOSIS OF FA
MOLECULAR BASIS FOR FA AND HNSCC
THE FUTURE
AUTHOR INFORMATION
Carter Van Waes, MD, PhD
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RELATED ARTICLE
Fanconi Anemia: Adult Head and Neck Cancer and Hematopoietic Mosaicism
Blanche P. Alter, Hans Joenje, Anneke B. Oostra, and Gerard Pals
Arch Otolaryngol Head Neck Surg. 2005;131(7):635-639.
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