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Clinical Trial Registration
A Statement From the International Committee of Medical Journal Editors
Arch Otolaryngol Head Neck Surg. 2005;131:479-480.
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Altruism and trust lie at the heart of research on human subjects. Altruistic individuals volunteer for research because they trust that their participation will contribute to improved health for others and that researchers will minimize risks to participants. In return for the altruism and trust that make clinical research possible, the research enterprise has an obligation to conduct research ethically and to report it honestly. Honest reporting begins with revealing the existence of all clinical studies, even those that reflect unfavorably on a research sponsor’s product.
Unfortunately, selective reporting of trials does occur, and it distorts the body of evidence available for clinical decision-making. Researchers (and journal editors) are generally most enthusiastic about the publication of trials that show either a large effect of a new treatment (positive trials) or equivalence of 2 approaches to treatment (noninferiority trials). Researchers (and journals) typically are less excited about trials that show that . . . [Full Text of this Article]
Catherine D. DeAngelis, MD, MPH;
Jeffrey M. Drazen, MD;
Frank A. Frizelle, MBChB, MMedSc, FRACS;
Charlotte Haug, MD, PhD, MSc;
John Hoey, MD;
Richard Horton, FRCP;
Sheldon Kotzin, MLS;
Christine Laine, MD, MPH;
Ana Marusic, MD, PhD;
A. John P. M. Overbeke, MD, PhD;
Torben V. Schroeder, MD, DMSc;
Hal C. Sox, MD;
Martin B. Van Der Weyden, MD
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