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Arch Otolaryngol Head Neck Surg. 2005;131:175-176.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Postirradiation sinonasal osteosarcoma

Postirradiation sarcoma is a rare long-term complication of radiation treatment. Taghian et al¹ reported a 10-year cumulative incidence of 0.2% for sarcoma after radiation therapy. According to Laskin et al,² osteosarcoma accounted for 13% of postirradiation sarcomas, and several authors have reported that 6% to 15% of patients with osteosarcoma of the head and neck had a history of irradiation.³

The incidence of osteosarcoma is dramatically increased among survivors of retinoblastoma, among whom germline mutations of the retinoblastoma (Rb) gene are common. Also, some authors suggest that germline mutations in the p53 gene may increase the risk for osteosarcoma.⁴ Therefore, loss of function of the p53 and Rb tumor suppressor genes is believed to play an important role in tumorigenesis of osteosarcoma.

Microscopically, osteosarcoma is composed of malignant, spindle-shaped mesenchymal cells, associated with osteoid and immature neoplastic bone formation. The nucleus of the cell shows considerable hyperchromasia or . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2005;131(2):173.
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