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Gefitinib Therapy for Life-Threatening Laryngeal Papillomatosis
Bruce Bostrom, MD;
James Sidman, MD;
Stephen Marker, MD;
Timothy Lander, MD;
Dennis Drehner, DO
Arch Otolaryngol Head Neck Surg. 2005;131:64-67.
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INTRODUCTION
Respiratory papillomatosis is a potentially life-threatening condition that is caused by a human papillomavirus infection of the respiratory epithelium.1-2 Patients whose condition is diagnosed at a younger age are at high risk for recurrent aggressive disease.3 The primary management approach focuses on the removal of the papillomas by surgical debulking, although persistence of the human papillomavirus genome with subsequent recurrence of disease are the typical outcome. In a minority of patients, surgical management must be supplemented with adjuvant medical therapy, with interferon being the best studied and most commonly used. Other adjuvant treatments include photodynamic therapy, indole-3-carbinol, mumps immunization, ribavirin, and cidofovir.4 Large controlled trials are lacking for all such treatments other than interferon, making it extremely difficult to assess clinical benefit and risk in a systematic fashion at the current time. As with surgical . . . [Full Text of this Article]
REPORT OF A CASE
COMMENT
AUTHOR INFORMATION
Author Affiliations: Divisions of Pediatric Hematology Oncology (Dr Bostrom) and Pathology (Dr Drehner), Children’s Hospitals and Clinics, Pediatric ENT Associates (Drs Sidman and Lander), and Division of Pediatric Infectious Disease, Park-Nicollet Clinic (Dr Marker), Minneapolis, Minn.
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