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Pathology Quiz Case 2—Diagnosis
Arch Otolaryngol Head Neck Surg. 2004;130:477-478.
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Diagnosis: Primary mucosal melanoma of the nasal cavity
Histopathologic examination showed a high-grade neoplasm composed of polygonal, epithelioid cells with significant nuclear pleomorphism (Figure 3) and a high mitotic index. Areas of tumor necrosis and brownish pigmentation were present. On immunohistochemical analysis, tumor cells were diffusely positive for S100 protein and HMB-45 (Figure 4 ). A diagnosis of sinonasal melanoma (SNM) was made. Radiography of the chest, ultrasonography of the abdomen, and a total-body computed tomographic scan ruled out regional and distant metastases. The cosmetic outcome was excellent, and after a 40-month follow-up period, the patient was still free of disease.
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Mucosal melanoma of the nasal cavity is a rare neoplasm that occurs equally in men and women. The median age at presentation is the late 60s.1-2 Sinonasal melanoma frequently arises in the anterior nasal septum, as well as in the middle and lower turbinates. Mucosal melanosis has been found to . . . [Full Text of this Article]
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Pathology Quiz Case 2
Donato Calista, Massimo Morri, Luca Riccioni, Massimo Bassi, and Claudio Marchetti
Arch Otolaryngol Head Neck Surg. 2004;130(4):475.
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