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Arch Otolaryngol Head Neck Surg. 2004;130:368.

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Diagnosis: Multiple myeloma with an extramedullary plasmacytoma involving the subglottis

Plasma cell neoplasms most commonly involve the bone marrow in a diffuse fashion (multiple myeloma), but they may also present as a localized lesion of bone (solitary plasmacytoma of bone) or soft tissues (extramedullary plasmacytoma [EMP]), or any combination thereof. Extramedullary plasmacytomas account for less than 1% of all head and neck neoplasms, with approximately 80% occurring in the head and neck. The most common site involved is the sinonasal region (44%); only 11% of EMPs involve the larynx (<100 cases have been reported).¹ Most patients are men (male-female ratio, 3-4 to 1)² older than 50 years.³

The most common site of EMP within the larynx is the supraglottic region. Presenting symptoms include hoarseness, dysphagia, and airway obstruction. Typically, the symptoms are present for months before diagnosis. Laryngeal EMP usually presents as a submucosal mass. The literature discusses the difficulty in obtaining a biopsy specimen that is representative of the . . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2004;130(3):366.
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