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Pathology Quiz Case 2Diagnosis
Arch Otolaryngol Head Neck Surg. 2004;130:241-242.
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Diagnosis: Primary intestinal-type sinonasal adenocarcinoma
Adenocarcinoma, which accounts for 10% to 20% of all primary malignancies of the nasal cavity and adjacent sinuses, most commonly arises from minor salivary or seromucinous glands.1-2 Intestinal-type adenocarcinoma (ITAC) is a rare subtype that accounts for approximately 4% of all sinonasal adenocarcinomas.3 It appears to be unrelated to salivary gland neoplasia2 and may arise from mucus-secreting ("cylinder") cells of the respiratory mucosa. Sinonasal ITAC has been recognized as a specific disease entity for a century, but a significant association was made between ITAC and industrial wood exposure only 40 years ago, with a 500- to 1000-fold increase in risk for long-time woodworkers compared with the general population.4 Our patient had a significant history of wood-dust exposure through his past profession as well his recent hobby and had been personally building a home shortly before presenting to the emergency department. Patients with such exposure account for about 20% of cases,1 . . . [Full Text of this Article]
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Pathology Quiz Case 2
David A. Lehman, Giovana R. Thomas, and Jacinto Regalado
Arch Otolaryngol Head Neck Surg. 2004;130(2):239.
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