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  Vol. 130 No. 1, January 2004 TABLE OF CONTENTS
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  Clinical Problem Solving: Pathology
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 •Inflammatory Disease of Head & Neck
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Pathology Quiz Case—Diagnosis

Arch Otolaryngol Head Neck Surg. 2004;130:116.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Sclerosing sarcoidosis of the larynx

Laryngeal sarcoidosis, which was described by Poe1 in 1940, is a potentially life-threatening disease.2 However, it usually responds well to systemic therapy. The case reported herein represents an unusual presentation of the more aggressive cicatricial laryngeal sarcoidosis, which resulted in multiple recurrences that required tracheostomies. Pathologic examination revealed multiple nonnecrotizing epithelioid granulomas with extensive sclerosis. This typical appearance, in the absence of identifiable organisms, is consistent with the diagnosis of laryngeal sclerosing sarcoidosis.

Sarcoidosis is a granulomatous disease of unknown etiology most commonly involving the lungs, the hilar and mediastinal lymph nodes, and, less commonly, the spleen, liver, eyes, skin, bone, and nervous system.3-4 Onset usually occurs during the third to fifth decades of life, with a predilection for African Americans. Acute sarcoidosis may be self-limited or progress to chronic disease that requires corticosteroid therapy. The most common cause of death is pulmonary fibrosis or cardiac or central nervous system . . . [Full Text of this Article]







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