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Arch Otolaryngol Head Neck Surg. 2003;129:680-681.

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Diagnosis: Cribriform-morular variant of papillary thyroid carcinoma

The pathologic diagnosis of papillary thyroid carcinoma includes several histologic variants, such as the tall cell, columnar cell, oxyphil cell, diffuse sclerosing, poorly differentiated, diffuse follicular, and hyalinizing trabecular types.^1-2 The presence of these features may be clinically significant, particularly in the cases of the tall cell and diffuse sclerosing variants, which are associated with poorer clinical outcomes.

Histopathologically, the cribriform-morular variant displays a mixture of papillary, follicular, cribriform, trabecular, morular, and solid growth patterns.² The papillary areas tend to have tall or cuboidal cells that, on higher magnification, demonstrate the typical nuclear features of papillary thyroid carcinoma, including a ground glass appearance with prominent nucleoli and nuclear grooving. The cribriform areas demonstrate back-to-back follicles with no intervening stroma. Also, these follicles do not typically contain colloid. The back-to-back follicles and the lack of colloid are shown in Figure 1. The solid areas, which are demonstrated in Figure 2. . . [Full Text of this Article]

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Arch Otolaryngol Head Neck Surg. 2003;129(6):679.
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