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We thank Prof Sampson for his comments. As he mentioned in his letter, for a long time no product was approved for peripheral vertigo by the FDA. The fact that there were no appropriate treatments for Meniere disease and that vertiginous patients benefited from a nonspecific or placebo effect of therapy was yet concluded by Torok¹ in 1977. In the meantime the current knowledge of the pathogenesis and treatment of vertigo and especially of Meniere disease gained increasing data quality. Twenty years later Claes and van de Heyning² discussed the vestibular sedative, antiemetic, vasoactive, and diuretic effects of a couple of substances that are used in the treatment of Meniere disease in their review of literature. Betahistine is described as significantly more effective than placebo in 2 of 3 double-blind, randomized clinical trials, with a more favorable effect than a diuretic or piperazine comparator.^2-3

Betahistine is a histamine . . . [Full Text of this Article]

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