
The Use of Genetic Markers in the Clinical Care of Patients With Head and Neck Cancer
Arch Otolaryngol Head Neck Surg. 2003;129:363-366.
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Hypothesis: Genetic markers are not currently useful in the clinical care of patients with head and neck cancer.
BACKGROUND
During the past few years, there has been an explosion in the number of articles investigating genetic markers and head and neck cancer. This is interesting for the scientist but confusing for the clinician. It is difficult to decipher the utility of the "alphabet soup" of molecular markers found in the literature. The genes described are unfamiliar to most otolaryngologists treating patients with head and neck cancer, and the articles are confounded by conflicting data.
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The investigation of molecular markers of head and neck cancers is certainly intellectually challenging. The real question for the clinician is, Will these data translate into improvements in locoregional control and survival? The present article will investigate the current clinical utility of molecular markers and comment on the hypothesis that these markers are . . . [Full Text of this Article]
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