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  Vol. 129 No. 11, November 2003 TABLE OF CONTENTS
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  •  Online Features
  Clinical Problem Solving: Pathology
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 •Laryngology/ Speech/ Language Pathology
 •Neoplasms of Head & Neck
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Pathology Quiz Case

Y. Etan Weinstock, BA; David Myssiorek, MD; Ning Cai, MD; Nora Morgenstern, MD
Long Island Jewish Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, NY

Arch Otolaryngol Head Neck Surg. 2003;129:1243.

Since this article does not have an abstract, we have provided the first 142 words of the full text and any section headings.

A 52-YEAR-OLD MAN underwent radiation therapy 2 years prior to presentation for a stage I laryngeal cancer involving the subglottic anterior commissure. An emergent tracheotomy was performed for airway obstruction. He had a history of long-term tobacco use and alcohol abuse. Direct laryngoscopy and biopsy revealed a large ulcerative polypoid mass involving the glottis and supraglottic areas. Representative hematoxylin-eosin–stained sections of the biopsy specimen are shownin Figure 1 (black arrow indicates spindle cell component; white arrow, squamous cell component [original magnification x100]) and Figure 2 (arrows indicate spindle cells [original magnification x400]). Immunohistochemical analysis of the specimen (Figure 3) revealed that its cells were reactive for epithelial antigens (arrow indicates positive staining with high-molecular-weight keratin).


 
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Figure 1.



 
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Figure 2.



 
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Figure 3.


What is your diagnosis?

SECTION EDITORS: FREDERIC B. ASKIN, MD; WILLIAM H. WESTRA, MD



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RELATED ARTICLE

Pathology Quiz Case—Diagnosis
Arch Otolaryngol Head Neck Surg. 2003;129(11):1244-1245.
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