
Pathology Quiz Case
Y. Etan Weinstock, BA;
David Myssiorek, MD;
Ning Cai, MD;
Nora Morgenstern, MD
Long Island Jewish Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, NY
Arch Otolaryngol Head Neck Surg. 2003;129:1243.
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A 52-YEAR-OLD MAN underwent radiation therapy 2 years prior to presentation for a stage I laryngeal cancer involving the subglottic anterior commissure. An emergent tracheotomy was performed for airway obstruction. He had a history of long-term tobacco use and alcohol abuse. Direct laryngoscopy and biopsy revealed a large ulcerative polypoid mass involving the glottis and supraglottic areas. Representative hematoxylin-eosinstained sections of the biopsy specimen are shownin Figure 1 (black arrow indicates spindle cell component; white arrow, squamous cell component [original magnification x100]) and Figure 2 (arrows indicate spindle cells [original magnification x400]). Immunohistochemical analysis of the specimen (Figure 3) revealed that its cells were reactive for epithelial antigens (arrow indicates positive staining with high-molecular-weight keratin).
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Figure appears in full text version.
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SECTION EDITORS: FREDERIC B. ASKIN, MD; WILLIAM H. WESTRA, MD
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Arch Otolaryngol Head Neck Surg. 2003;129(11):1244-1245.
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