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  Vol. 129 No. 1, January 2003 TABLE OF CONTENTS
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  Clinical Problem Solving: Pathology
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Pathology Quiz Case—Diagnosis

Arch Otolaryngol Head Neck Surg. 2003;129:128.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Granular cell tumor of the tongue, with extensive overlying pseudoepitheliomatous hyperplasia

Granular cell tumors are unusual neoplasms that were first described in 1926 by Abrikossoff.1 About 50% of granular cell tumors occur in the head and neck, and of these, more than half occur on the tongue,2-4 where they have been reported on the tip, dorsum, lateral border, base, and ventral surface.2 Other sites in the head and neck area include the buccal mucosa, lips, palate, larynx, trachea, orbit, esophagus, and cranial nerves.2-3 Most granular cell tumors are benign. Only about 2% exhibit malignant features.3-5 Metastatic granular cell tumors must be distinguished from local recurrences and benign multifocal tumors.5

Granular cell tumors occur more often in females (female-male ratio, 2:1) and are most frequently seen in the fourth through sixth decades of life.2, 4 They commonly present as a solitary, firm, painless mass that can be submucosal, polypoid, or sessile. Mucosal ulceration is rare.2 White areas caused by colonization with Candida are . . . [Full Text of this Article]



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RELATED ARTICLE

Pathology Quiz Case
Jeffrey P. Simons, Jennifer L. Hunt, and Jonas T. Johnson
Arch Otolaryngol Head Neck Surg. 2003;129(1):127.
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