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Central Mucoepidermoid Carcinoma of the Mandible
Tumorigenesis Within a Keratocyst
F. Christopher Holsinger, MD;
Jonathan M. Owens, MD;
A. Kevin Raymond, MD;
Jeffrey N. Myers, MD, PhD
Arch Otolaryngol Head Neck Surg. 2002;128:718-720.
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INTRODUCTION
Mucoepidermoid carcinomas account for 15% of all salivary gland tumors.
The vast majority (60%) occur in the parotid gland, with the remainder arising
in the submandibular gland and minor salivary glands.1
Mucoepidermoid carcinoma arising within the maxilla or mandible, known as
central mucoepidermoid carcinoma (CMC), is a far less common entity, with
fewer than 200 cases reported in the English-language literature.
The pathogenesis of CMC remains controversial. Heterotopic rests of
normal salivary gland tissue are found commonly in many sites, including the
mandible.2 Several theories of their origin
have been postulated3: (1) entrapment of retromolar
mucous glands within the mandible, (2) developmentally included embryonic
remnants of submandibular glands within the mandible, and (3) neoplastic transformation
of mucus-secreting cells in the epithelial lining of odontogenic cysts.
REPORT OF A CASE
An 18-year-old African American man presented to . . . [Full Text of this Article]
COMMENT
From the Bobby R. Alford Department of Otorhinolaryngology and Communicative
Sciences, Baylor College of Medicine, Houston, Tex (Dr Holsinger); the Department
of Otolaryngology and Head and Neck Surgery, University of Colorado Health
Sciences Center, Denver (Dr Owens); and the Departments of Pathology (Dr Raymond)
and Head and Neck Surgery (Dr Myers), The University of Texas M. D. Anderson
Cancer Center, Houston.
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