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Arch Otolaryngol Head Neck Surg. 2001;127:1144.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Dr Hom is to be congratulated for his extensive review of the current and historical literature on this topic. The keloid represents a challenging wound-healing dilemma, lacking uniform treatment guidelines. Clinical experience, compounded by the findings of a variety of clinical series, confirms the lack of a foolproof protocol in treating this form of scar. The keloid is an abnormal tissue response to trauma in which fibroblasts deposit an overabundance of collagen, fibronectin, and extracellular matrix. The ensuing cicatrix is composed of randomly aligned collagen bundles that grow beyond the boundaries of the original wound.

Hom is correct in pointing out the problems in interpreting the findings of studies on keloids because of the lack in uniformity of design, lack of appropriate follow-up (at least 12 months), lack of definition of clinical response, and failure to distinguish hypertrophic scars from keloids. It should be mentioned that variations in appearance have . . . [Full Text of this Article]

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