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Anil V. Parwani, MD, PhD; Robert W. Allan, MD; William H. Westra, MD; Robert Udelsman, MD; Douglas W. Ball, MD; Pedram Argani, MD
Baltimore, Md

Arch Otolaryngol Head Neck Surg. 2001;127:594-597.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

AN ASYMPTOMATIC 9-year-old girl with normal childhood development was referred for DNA sequence analysis of the RET proto-oncogene on chromosome 10. She was the daughter of a woman with multiple endocrine neoplasia syndrome type 2A (MEN-2A). Genetic testing revealed a mutation involving codon 618 of the RET proto-oncogene that changed the wild-type TGC codon to a TCC codon. Her mother and 6-year-old sister carried the identical germline mutation of the RET proto-oncogene. Her serum calcitonin level was 40 ng/L (reference range, 0-4 ng/L). She underwent a total thyroidectomy with central lymph node dissection. Intraoperatively, there was no evidence of cervical lymphadenopathy, and the thyroid gland appeared normal.

The thyroid gland was grossly normal, without palpable or visible masses. The histopathologic findings of sections obtained from the right . . . [Full Text of this Article]

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