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Pathology Quiz Case 2
Ming-Yin Lan, MD;
Yuan-Ching Guo, MD;
Pen-Yuan Chu, MD;
Donald Ming-Tak Ho, MD;
Shyue-Yih Chang, MD
Taipei, Taiwan
Arch Otolaryngol Head Neck Surg. 2001;127:1503-1505.
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A 68-YEAR-OLD man presented with a 2-month history of hoarseness. He
did not smoke or consume alcohol. Stroboscopic evaluation of his larynx revealed
a smooth-surfaced bulging mass, without mucosal waves, over the middle third
of the right vocal cord (Figure 1).
Physical examinations revealed that there were no palpable masses or lymphadenopathy.
Microlaryngoscopy was performed with the patient under general anesthesia.
Although the lesion was initially thought to represent a vocal cord cyst,
it was found to have a firm consistency on instrumental palpation. Excisional
biopsy was performed.
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Figure 1.
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Histological examination showed a spindle cell tumor with moderate nuclear
pleomorphism and brisk mitotic activity (Figure 2). The tumor cells were immunoreactive for vimentin, smooth
muscle actin (Figure 3), and desmin.
They were not immunoreactive for cytokeratin (AE1/AE3) . . . [Full Text of this Article]
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