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Important Ideas Emerge From Multidisciplinary Training

Arch Otolaryngol Head Neck Surg. 1999;125:1237-1238.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ARTICLE by Terry Shibuya and colleagues¹ in this issue of the ARCHIVES deserves special attention for several reasons. First, it contains new information that has broad multidisciplinary interest but is particularly important for the specialist in head and neck cancer. These investigators report that modification of surgical suture by coating it with anti-CD3/anti-CD28 monoclonal antibodies (MoAbs) leads to enhancement of immune functions in T lymphocytes obtained from the peripheral blood of healthy individuals as well as from the blood or lymph nodes of patients with squamous cell carcinoma of the head and neck. The MoAbs used by Shibuya et al have long been known to induce in vitro T-cell activation when coated onto the surface of plastic plates. Placed on the plastic surface, these MoAbs effectively cross-link the receptors on T lymphocytes (ie, T-cell receptors, of which the CD3 molecule is a part, as well as costimulatory CD28 receptors), . . . [Full Text of this Article]

RELATED ARTICLE

Anti-CD3/Anti-CD28 Monoclonal Antibody–Coated Suture Enhances the Immune Response of Patients With Head and Neck Squamous Cell Carcinoma
Terry Y. Shibuya, Wei-Zen Wei, Michelle Zormeier, John Ensley, Wael Sakr, Robert H. Mathog, Robert J. Meleca, George Yoo, Carl H. June, Bruce Levine, and Lawrence G. Lum
Arch Otolaryngol Head Neck Surg. 1999;125(11):1229-1234.
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