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"Molecular Margins"
A Better Measure?
Margaret Brandwein, MD;
David Yong Zhang, MD, PhD
From the Department of Otolaryngology, Mount Sinai School of Medicine, New York, NY.
Arch Otolaryngol Head Neck Surg. 1998;124:841-842.
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Since the introduction of the cold-chamber cryostat, the technique of frozen section analysis has changed little during the past 30 years.1 Frozen section analysis continues as a mainstay component of surgical resection, though it leads to an inherent tissue "tug-of-war" between the desire to preserve function and the intention to achieve adequate oncological clearance. The technique is not without limitations. Retraction of skeletal muscle around a carcinoma adds vagary to the goal of securing a particular margin distance (eg,  5 mm). Sampling errors may cause false-negative results. Rarely, overinterpretation of radiation-induced changes or dysplasia extending into salivary ducts may result in false-positive readings. Finally, complete resection may not be possible for some tumors, despite intraoperative tissue sampling. Still, the technique of frozen sections remains a useful tool.
Barrera and colleagues,2 in this issue of the ARCHIVES, sample squamous cell carcinomas and adjacent . . . [Full Text of this Article]
RELATED ARTICLE
Malignancy Detection by Molecular Cytogenetics in Clinically Normal Mucosa Adjacent to Head and Neck Tumors
José E. Barrera, Hong Ai, Zhaoxing Pan, Arlen D. Meyers, and Marileila Varella-Garcia
Arch Otolaryngol Head Neck Surg. 1998;124(8):847-851.
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