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Ototoxic Drug Effects on Cochlear Histochemistry
Yoshihiro Kaku, MD;
Joseph C. Farmer, Jr., MD;
William R. Hudson, MD
Arch Otolaryngol. 1973;98(4):282-286.
Abstract
Cochlear histochemical changes after administration of kanamycin sulfate and ethacrynic acid were studied in normal guinea pigs. The activities of cochlear succinic dehydrogenase and reduced diphosphopyridine nucleotide diaphorase were more suppressed by a large amount of kanamycin administered over a shorter duration than by a moderate amount given over a longer duration and were suppressed by ethacrynic acid given intravenously in one large dose or by middle ear injection.
Both ethacrynic acid and kanamycin had a greater effect on the respiratory enzyme activities of the basal turn than the other turns. Kanamycin had a greater effect on cochlear respiratory enzyme activities than on adenosine triphosphatase (ATPase) activity. Ethacrynic acid, in the doses given, had no effect on cochlear ATPase activity.
Author Affiliations
Durham, NC
From the Division of Otolaryngology, Department of Surgery, Duke University Medical Center, Durham, NC. Read before the 15th annual meeting of the Committee for Research in Otolaryngology, American Academy of Ophthalmology and Otolaryngology, Las Vegas, Sept 18, 1971.
Footnotes
Accepted for publication Sept 14, 1972.
Reprint requests to Division of Otolaryngology, Duke University Medical Center, Durham, NC 27710 (Dr. Hudson).
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