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Biochemical Evidence and the Metabolic Consequences

Charles E. Holdsworth, PhD; Gerald L. Endahl, PhD; Nathaniel Soifer, MD; Keith E. Richardson, PhD

Arch Otolaryngol. 1973;98(3):191-195.

Abstract
The sensitivity of phosphofructokinase to stimulation by sulfate, adenosine monophosphate, and cyclic adenosine monophosphate is decreased in otosclerosis. The enzyme is unresponsive to inhibition by a citrate and markedly stimulated by lactate, normally not an effector.

The evidence suggests that aberrant phosphofructokinase is operative in otosclerosis. This would cause defective regulation of glycolysis and a consequent imbalance between the anaerobic and aerobic phases of metabolism. Evidence from this and other studies supports the conclusion that otosclerotic bone is abnormally geared to a primarily aerobic metabolism.

Author Affiliations
Columbus, Ohio; Los Angeles; Dayton, Ohio; Columbus, Ohio

From the Department of Physiological Chemistry, Ohio State University, Columbus, Ohio (Drs. Holdsworth and Richardson); University of Southern California, Los Angeles (Dr. Endahl); and the Good Samaritan Hospital, Dayton, Ohio (Dr. Soifer).

Footnotes
Accepted for publication Aug 24, 1972.

Reprint requests to 6400 Brushwood Ct, Dayton, OH 45415 (Dr. Holdsworth).

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