This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Severe Cochlear Damage in Guinea Pigs

Bud A. West, MD; Robert E. Brummett, PhD; Donna L. Himes

Arch Otolaryngol. 1973;98(1):32-37.

Abstract
The clinical observation that ethacrynic acid administration to patients receiving kanamycin therapy can result in a permanent hearing loss has been verified in experimental animals. We have demonstrated that guinea pigs receiving a loading dose of 400 mg/kg of kanamycin subcutaneously, followed in two hours by an intravenous injection of 40 mg/kg of ethacrynic acid, lose their cochlear function permanently. The effect occurs approximately two hours after the injection of ethacrynic acid and seems to occur by a different mechanism than that which produces the initial temporary effect previously reported. Because of this possible interaction, caution must be exercised when employing an aminoglycoside antibiotic and ethacrynic acid together in patients with renal failure.

Author Affiliations
Portland, Ore

From the University of Oregon Medical School, Kresge Hearing Research Laboratory, Portland.

Footnotes
Accepted for publication Aug 24, 1972.

Reprint requests to University of Oregon Medical School, Kresge Hearing Research Laboratory, Portland, OR 97201 (Dr. Brummett).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sensorineural hearing loss and prematurity
Marlow et al.
Arch. Dis. Child. Fetal Neonatal Ed. 2000;82:141F-144.
ABSTRACT | FULL TEXT  

A Sensitive Animal Model to Assess Acute and Chronic Ototoxic Effects
Lautermann and Schacht
Arch Otolaryngol Head Neck Surg 1996;122:837-840.
ABSTRACT  

The Neurotoxicity of Antibacterial Agents
SNAVELY and HODGES
ANN INTERN MED 1984;101:92-104.
ABSTRACT  

Potentiating Effects of Cisplatin and Ethacrynic Acid in Ototoxicity
Komune and Snow
Arch Otolaryngol Head Neck Surg 1981;107:594-597.
ABSTRACT  

Comparative Ototoxicity of Chloramphenicol and Kanamycin With Ethacrynic Acid
Beaugard et al.
Arch Otolaryngol Head Neck Surg 1981;107:104-109.
ABSTRACT  

Quantitative Relationships of the Ototoxic Interaction of Kanamycin and Ethacrynic Acid
Brummett et al.
Arch Otolaryngol Head Neck Surg 1979;105:240-246.
ABSTRACT  

Tobramycin Ototoxicity: A Second Look
Brummett and Brown
Arch Otolaryngol Head Neck Surg 1975;101:540-543.
ABSTRACT  

Ototoxicity of Ethacrynic Acid in the Anuric Guinea Pig
McCurdy et al.
Arch Otolaryngol Head Neck Surg 1974;100:143-147.
ABSTRACT