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A Comparative Study of the Ototoxicity of Tobramycin and Gentamicin
Robert E. Brummett, PhD;
Donna Himes;
Brian Saine, MD;
Jack Vernon, PhD
Arch Otolaryngol. 1972;96(6):505-512.
Abstract
Dose response experiments were conducted on guinea pigs comparing the toxic liability of tobramycin and gentamicin on cochlear electrophysiology and histology. Parallel curves were obtained for the effect on the alternating current cochlear potential and hair cell destruction. In all cases the most damaging effect was produced by gentamicin.
Author Affiliations
Portland, Ore
From the University of Oregon Medical School, Department of Otolaryngology, Portland, Ore.
Footnotes
Accepted for publication Feb 5, 1972.
Reprint requests to University of Oregon Medical School, Kresge Hearing Research Laboratory, 3515 SW Veterans Road, Portland, Ore 97201 (Dr. Brummett).
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