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J. Edward Dempsey, MD; Richard T. Jackson, PhD

Arch Otolaryngol. 1972;96(3):216-219.

Abstract
The effectiveness of pseudoephedrine hydrochloride (a sympathomimetic) and triprolidine hydrochloride (an antihistamine) was tested on the dog's eustachian tube. Triprolidine appeared to be an effective antihistamine at clinical doses. It significantly reduced the tube's response to exogenous histamine. Pseudoephedrine increased the patency of the eustachian tube. However, tachyphylaxis was one of the drugs' prominent features. Tachyphylaxis occurred most often when given intravenously or intra-arterially and least often when applied topically. The significance of tachyphylaxis to drug prescribing is discussed.

Author Affiliations
Atlanta

From the Division of Otolaryngology, Emory University School of Medicine, Atlanta.

Footnotes
Accepted for publication Jan 11, 1972.

Emory University Basic Health Sciences Publication No. 1046.

Reprint requests to 441 Woodruff Memorial Bldg. Emory University, Atlanta 30322 (Dr. Jackson).

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