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A Comparison of Routes of Administration

Leo J. Davis, MD; Philip A. Sheffield, MD; Richard T. Jackson, PhD

Arch Otolaryngol. 1970;92(4):325-328.

Abstract
This report is a survey of the patency responses of a dog's eustachian tube to some important pharmacologic agents. Drugs were introduced by three routes: intra-arterial, intravenous, and topical. The patency change of the eustachian tube to a particular drug was usually the same regardless of the route of administration. Patency changes could usually be elicited with drug doses given in the nanogram or microgram range. Large blood pressure changes altered the patency changes and, in some cases, reversed their direction. Of the 13 drugs tested, levarterenol and prostaglandin E₁ did not exhibit "typical" behavior. When these two drugs were given topically, the direction of the patency response depended on the dose.

Author Affiliations
Atlanta

From the Joseph B. Whitehead Department of Surgery (Division of Otolaryngology), Emory University Schoool of Medicine, Atlanta.

Footnotes
Accepted for publication March 30, 1970.

Read before the American Academy of Ophthalmology and Otolaryngology, Chicago, Oct 11, 1969.

Reprint requests to 441 Woodruff Memorial Bldg, Emory University, Atlanta 30322 (Dr. Richard

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