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Experimental Microembolization Of Cochlear Vessels
Fumiro Suga, MD, MedScD;
Jack Preston, MD;
James B. Snow, Jr., MD
Arch Otolaryngol. 1970;92(3):213-220.
Abstract
Microembolization of the cochlear vessels with a suspension of barium sulfate produces a decrease in the cochlear potential, eighth nerve action potential, and cochlear blood flow. One vasodilating agent, phenoxybenzamine hydrochloride (an  adrenergic blocking agent) appears to inhibit the deleterious effects of cochlear microembolization. The mechanism of this protection appears to be the prevention of reflex vasospasm in response to microembolization. Histopathologic examination of the temporal bones of the microembolized chronic animals reveals dilatation of the cochlear duct, degeneration of the organ of Corti and stria vascularis, and proliferation of fibrous and bony tissue into the cochlear lumen.
Author Affiliations
Oklahoma City
From the of Department of Otorhinolaryngology, University of Oklahoma Medical Center, Oklahoma City.
Footnotes
Accepted for publication March 23, 1970.
Read in part before the 52nd annual meeting of the Federation of American Societies for Experimental Biology, Atlantic City, NJ, April 17, 1968, and the 12th annual meeting of the Committee for Research in Otolaryngology, American Academy of Ophthalmology and Otolaryngology, Chicago, Oct 26, 1968.
Repring requests to Department of Otorhinolaryngology, University of Oklahoma Medical Center, 800 NE 13th St, Oklahoma City 73104 (Dr. Snow).
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