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A Preliminary Study

Robert H. Mathog, MD; William G. Thomas, PhD; William R. Hudson, MD

Arch Otolaryngol. 1970;92(1):7-13.

Abstract
The ototoxicity of ethacrynic acid and furosemide is studied in cats utilizing round window electrodes and light microscopy. Both diuretics produce a primary depression of the cochlear microphonic and action potential with almost complete recovery in one hour. Depending upon the dosage and method of administration a severe secondary depression may develop with ethacrynic acid. This delayed depression is associated with the appearance of outer hair cell degeneration in the basal and middle coils of the cochlea.

Author Affiliations
Durham, NC

From the Division of Otolaryngology, Department of Surgery, Duke University Medical Center, Durham, NC. Dr. Mathog is now a major with the US Air Force Medical Corps, Otolaryngology Branch, USAF School of Aerospace Medicine, Brooks Air Force Base, San Antonio, Tex.

Footnotes
Accepted for publication Nov 25, 1969.

Reprint requests to Division of Otolaryngology, Duke University Medical Center, Durham, NC 27706 (Dr. Hudson).

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