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Raymond Carhart, PhD; Eugene L. Derlacki, MD

Arch Otolaryngol. 1970;91(4):376-377.

Abstract
Any chromosomal abnormalities associated with otosclerosis would be most likely to appear among persons exhibiting familial otosclerosis. Blood from 13 otosclerotics representing three families was analyzed by short-term culture of peripheral blood leukocytes. The four men exhibited normal male karyotype (46,XY) and the nine women normal female karyotype (46,XX). The findings do not confirm the contention by Tato et al¹ that otosclerotics are characterized by peculiarity of chromosomal number and morphology.

Author Affiliations
Chicago

From the Department of Otolaryngology and Maxillofacial Surgery, Medical School, Northwestern University, Chicago.

Footnotes
Accepted for publication Jan 6, 1970.

Reprint requests to Northwestern University Speech Annex Bldg, Room 41, Evanston, Ill 60201 (Dr. Carhart).

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