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Thomas S. Main, MD; Tadao Shimada, MD; David J. Lim, MD

Arch Otolaryngol. 1970;91(4):356-359.

Abstract
Cholesterol granulomas were produced in the mastoid cavity of the squirrel monkey by obstructing the eustachian tube with silicone-rubber (Silastic) sponges. It was noted that these granulomas developed only in the mastoid cells, which is suggestive that isolation of hemorrhage in a small area without ventilation is an important factor in the genesis of cholesterol granulomas. Our experiment favors the concept that hemorrhage in mastoid air cells, possibly due to negative pressure, has a vital role in the pathogenesis of this disease.

Author Affiliations
Columbus Ohio

From the Otological Research Laboratories, Department of Otolaryngology, the Ohio State University Medical School, Columbus, Ohio.

Footnotes
Accepted for publication Jan 6, 1970.

Reprint requests to Otological Research Laboratories, Ohio State University Hospitals, 320 W Tenth Ave, Columbus, Ohio 43210 (Dr. Lim).

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