This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • General Rhinology  • Genetics of Head & Neck Disease  • Paranasal Sinus Disease  • Alert me on articles by topic

Ling-Feng Wang, MD; Chen-Yu Chien, MD; Wen-Rei Kuo, MD; Chin-Feng Tai, MD; Suh-Hang Hank Juo, MD, PhD

Arch Otolaryngol Head Neck Surg. 2008;134(8):852-856.

Objective  To systematically investigate the role of matrix metalloproteinase-2 (MMP2) tagging single nucleotide polymorphisms (SNPs) and promoter functional polymorphism in the development of nasal polyps in a Chinese population in Taiwan.

Design  We conducted a case-control study in 136 cases of chronic rhinosinusitis with bilateral nasal polyps and 136 controls. Seventeen SNPs were selected, including 16 tagging SNPs and 1 promoter functional SNP. The genotypes were determined by TaqMan technology. Hardy-Weinberg equilibrium was tested for each SNP, and genetic effects were evaluated according to 3 modes of inheritance. Subset analysis based on the recurrence of nasal polyps was also performed.

Setting  Medical university center hospital.

Results  All 17 SNPs were in Hardy-Weinberg equilibrium. When comparing the patients with recurrent nasal polyps and controls, none of the SNPs reached the significant level of P < .05 except rs857403. The AT genotype of rs857403 had an adjusted odds ratio of 2.07 (95% confidence interval, 1.09-3.95) (P = .03). However, the result became nonsignificant after including an additional 691 controls. Therefore, we considered that the initial significance was a false-positive finding. Neither haplotype analysis nor subset analysis yielded any significant result.

Conclusion  The MMP2 gene does not play a crucial role in conferring risk for nasal polyps in a Taiwanese population.

Author Affiliations: Department of Otolaryngology (Drs Wang, Kuo, and Tai), Graduate Institute of Medicine (Dr Chien), Graduate Institute of Medical Genetics and Center of Excellence for Environmental Medicine (Dr Juo), and Department of Otolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital (Dr Wang), Kaohsiung Medical University, Kaohsiung, Taiwan; and Departments of Otolaryngology (Drs Chien and Tai) and Medical Research (Dr Juo), Kaohsiung Medical University Hospital.