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L-myc Polymorphism in Head and Neck Nonmelanoma Skin and Lower Lip Cancers
Ayd n Gözü, MD;
Arzu Ergen, PhD;
Deniz Day c o lu, MD;
lhan Yayl m, PhD;
Zafer Özsoy, MD;
Turgay sbir, PhD
Arch Otolaryngol Head Neck Surg. 2008;134(7):725-728.
Objective To evaluate the presence of L-myc gene variations as a genetic predisposition to head and neck nonmelanoma skin cancer (HNNMSC) and lower lip cancer (LLC).
Design A case-control study.
Setting An academic institute laboratory.
Participants Twenty-four patients with HNNMSC and 27 with LLC were compared with 51 age- and sex-matched control subjects.
Main Outcome Measures Polymerase chain reaction restriction fragment length polymorphism and agarose gel electrophoresis were used to determine the L-myc oncogene genotypes.
Results The presence of the LS genotype was found to be significantly increased in the study group, whereas the LL genotype was not detected. The S allele was also more frequent in the study group. The SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer. Patients with LLC displayed significantly less of the SS genotype.
Conclusions The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
Author Affiliations: Department of Plastic and Reconstructive Surgery, Vakif Gureba Research and Education Hospital (Drs Gözü, Day c o lu, and Özsoy), and Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University (Drs Ergen, Yayl m, and sbir), Istanbul, Turkey.
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