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Effect of Topical Corticosteroid Treatment

Huabin Li, MD, PhD; Weiping Wen, MD, PhD; Lei Cheng, MD, PhD; Jianbo Shi, MD, PhD; Hongyan Jiang, MD, PhD; Yun Oh, MD; Geng Xu, MD, PhD

Arch Otolaryngol Head Neck Surg. 2008;134(3):301-305.

Objectives  To determine whether the chloride channel protein CLC-3 is upregulated in patients with allergic rhinitis (AR) and whether topical corticosteroid treatment decreases the expression of CLC-3.

Design  Histologic study.

Setting  Academic research.

Patients  Eighteen patients with AR were included in the study.

Main Outcome Measures  Expression of CLC-3 was detected by immunohistochemistry and by reverse transcription–polymerase chain reaction before and at 4 weeks after treatment with the topical corticosteroid mometasone furoate.

Results  Strong CLC-3 expression was detected in epithelium and in submucosal glands. An increased presence of CLC-3 was demonstrated in nasal mucosa compared with that in normal nasal tissue. A statistically significant difference in CLC-3 gene expression level was found in nasal tissues before vs at 4 weeks after treatment with mometasone.

Conclusions  CLC-3 may have a role in modulating the pathogenesis of AR. Decreased expression of CLC-3 may be the mechanism of action of corticosteroid treatment in controlling AR.

Author Affiliations: Otorhinolaryngology Hospital, First Affiliated Hospital, and Otorhinolaryngology Institute, Sun Yat-sen University, Guangzhou (Drs Li, Wen, Shi, Jiang, and Xu), and Department of Otolaryngology, First Affiliated Hospital, Nanjing Medical University, Nanjing (Drs Li and Cheng), People's Republic of China; and Head and Neck Center and Thoracic Center, The University of Texas M. D. Anderson Cancer Center, Houston (Dr Oh).

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