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Katherine A. Hutcheson, MS; Denise A. Barringer, MS; David I. Rosenthal, MD; Annette H. May, MA; Dianna B. Roberts, PhD; Jan S. Lewin, PhD

Arch Otolaryngol Head Neck Surg. 2008;134(2):178-183.

Objective  To describe swallowing physiology and functional outcomes at select intervals after definitive radiotherapy for laryngeal carcinoma. We also examined associations among patient, tumor, and treatment characteristics and swallowing outcomes.

Design  Retrospective review.

Setting  The University of Texas M. D. Anderson Cancer Center, Houston.

Patients  This study cohort included 40 patients who underwent definitive radiotherapy for laryngeal carcinoma (from February 2001 to June 2004).

Main Outcome Measures  Modified barium swallow (MBS) studies were performed for 32 patients at 3 test intervals following irradiation: less than 6 months, 6 to 11 months, and 12 or more months. We recorded the presence or absence of aspiration (sensate or silent), 5 pharyngeal phase disorders, and 2 structural abnormalities. We also recorded pretreatment dysphagia complaints, feeding tube dependency, T classification, disease site, mucositis grade, and radiotherapy schedule with or without chemotherapy.

Results  Eighty-four percent of patients (27 of 32) referred for MBS studies after undergoing radiotherapy aspirated; 44% (12 of 27) did so silently. Silent aspiration was more prevalent during MBS studies conducted 1 or more years after radiotherapy. Pharyngeal phase disorders were observed more frequently than structural abnormalities (P < .01). Most patients required a feeding tube (78% [31 of 40]); however, 52% of the tubes (16) were eventually removed. We found no significant association between the occurrence of aspiration and disease site, T classification, treatment regimen, or pretreatment variables (P > .05). Pretreatment and posttreatment levels of feeding tube dependency were significantly associated (P = .03). Patient-reported dysphagia before treatment did not predict posttreatment swallowing outcomes (P > .05).

Conclusions  Dysphagia is a common outcome after laryngeal preservation with radiotherapy. Contrary to expectations, few parameters that we measured were significantly associated with swallowing outcomes in our study.

Author Affiliations: Departments of Head and Neck Surgery (Mss Hutcheson, Barringer, and May and Drs Roberts and Lewin) and Radiation Oncology (Dr Rosenthal), University of Texas M. D. Anderson Cancer Center, Houston.

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