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Proinflammatory Cytokine Single Nucleotide Polymorphisms in Nasal Polyposis
Selim S. Erbek, MD;
Erkan Yurtcu, PhD;
Seyra Erbek, MD;
F. Belgin Atac, PhD;
Feride I. Sahin, MD, PhD;
Ozcan Cakmak, MD
Arch Otolaryngol Head Neck Surg. 2007;133(7):705-709.
Objective To investigate the association between nasal polyposis (NP) and single nucleotide polymorphisms of the proinflammatory cytokines IL (interleukin) 1 (the IL1A gene), IL-1β (the IL1B gene), and tumor necrosis factor (the TNFA gene).
Design Prospective case-control trial.
Setting Tertiary referral center.
Patients Eighty-two patients with NP and 106 healthy volunteers without sinonasal disease.
Main Outcome Measures Genotypes of IL1A (4845G, 4845T), IL1B (–511C, –511T) and TNFA (–238G, –238A and –308G, –308A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.
Results The 4845 GT and 4845 TT genotypes of the IL1A gene were associated with NP (P < .05). The frequency of the –511 CC genotype of the IL1B gene was significantly higher in patients with NP than in controls (P = .01). The frequency of the –511 CT genotype of IL1B was significantly higher (P = .01) in the controls than in the patients with NP. The –238 AA genotype of the TNFA gene was higher in the patients with NP than in the controls (P = .05). There was a significantly high risk of susceptibility to NP in patients with the –308 GA genotype of TNFA (P = .001). None of the genotypes of the proinflammatory cytokines were related to sex, the presence of atopy, asthma, or aspirin intolerance (P > .05).
Conclusion The IL1A (4845 GT and 4845 TT), IL1B (–511 CC), and TNFA (–238 AA and –308 GA) genotypes were associated with susceptibility to NP in our study population.
Author Affiliations: Departments of Otolaryngology (Drs S. S. Erbek, S. Erbek, and Cakmak) and Medical Biology and Genetics (Drs Yurtcu, Atac, and Sahin), Faculty of Medicine, Baskent University, Ankara, Turkey.
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